This is just to up date this thread since I wrote it originally with the Nuvi 550 in mind.
For the most part using Mapsource to load a route into the newer Nuvi's, 2XXX and above will get you in trouble. I have a work around for this.
1. Press the speed window and release it when you get to the odometer screen.
2. Press and hold the speedometer until you get the developers screen.
3. Scroll down until you get to where you change the device from MTP, mass transfer protocol to mass storage. You want to change it so any file manger program can read the device.
Note: back up your GPS including all hidden files first.
How to back up your Nuvi
The link tells you how.
4. Turn on your Nuvi and delete all favorites, (waypoints) and Trips, (routes).
You did back up everything first right.
5. Open Base Camp,( I really don't like this program), delete all waypoints and routes that are there. Back up this file if you want it later.
6. Withing nothing in BC import the route(s) from Mapsource (you have to save the Mapsource file first).
7. Now connect your Nuvi and when BC finally gets done reading it you can then send the route(s) to your Nuvi.
8. Verify its all on the Nuvi and your done.
This may also apply to 1XXX models also.