No need to remove it. Just check it once every year or two.
Some folks remove the anode rod to drain the water heater tank before freezing weather. Although this is necessary in most RVs, TMs have a different and easier method of draining. If you look under the TM on the utility (street) side, you will see four drain valves hanging down - two in front of the tire, and two toward the rear. Opening these valves gravity-drains the entire plumbing system. As you can see in this diagram from my TechStuff album
https://www.trailmanorowners.com/for...&pictureid=435
the water heater drains through one of those valves. Just open all four, turn on a couple hot and cold faucets to admit air, and the water drains out on the ground.
Bill